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Laboratoire de Mathieu Laplante

PUBLICATIONS (Mathieu Laplante) 

 

 

  • Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, Marsolais D, Bossé Y, Birsoy K, Laplante M. Amplification of Adipogenic Commitment by VSTM2A. Cell Rep. 2017 Jan 3;18(1):93-106.

 

  • Labbé SM, Mouchiroud M, Caron A, Lamoureux G, Gélinas Y, Freinkman E, Leconte R, Bossé Y, Chimin P, Festuccia WT, Richard D, Laplante M*. mTORC1 is required for brown adipose tissue recruitment and metabolic adaptation to cold. Scientific Reports, 2016

 

  • Caron A, Labbé SM, Mouchiroud M, Huard R, Richard D*, Laplante M*. (2016) DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance. Am J Physiol Regul Integr Comp Physiol, 2016 Jun 1;310(11):R1322-31 (*co-corresponding).

 

  • Carbonneau M, Germain AM, Gagné L, Lalonde ME, Motorina A, Guiot MC, Secco B, Vincent E, Tumber A, Hulea l, Oppermann U, Jones R, Laplante M, Toposirovic I, Petreca K, Huot ME, Mallette FA. (2016) The oncometabolite 2-hydroxuglutarate activates the mTOR signaling pathway. Nature Communications

 

  • Labbé SM, Caron A, Chechi K, Laplante M, Lecomte R, Richard D. (2016) Metabolic activity of brown, beige and white adipose tissues in response to chronic adrenergic stimulation in male mice. Am J Physiol Endocrinol Metab, 2016 Jul 1;311(1):E260-8

 

  • Caron A, Labbé SM, Lanfray D, Blanchard PG, Sabatini DM, Richard D*, Laplante M* (2016). Hypothalamic Deptor overexpression protects against high-fat diet induced obesity. Molecular Metabolism, 8; 5 (2):102-12. (*co-corresponding)

 

  • Lanfray D, Caron A, Roy MC, Laplante M, Morin F, Leprince J, Tonon MC, Richard D. (2016) Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. Elife, 2016 Feb 15;5. pii: e11742. doi: 10.7554/eLife.11742.

 

  • Caron A, Richard D, Laplante M (2015). The roles of mTOR complexes in lipid metabolism. Annu Rev Nutr., 2015;35:321-48.

 

  • Labbé SM, Caron A, Bakan I, Laplante M, Carpentier AC, Richard D (2015). In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis. FASEB J, 29(5):2046-58.

 

  • Sood A, Jeyaraju DV, Prudent J, Caron A, Lemieux P, McBride HM, Laplante M, Toth K, Pellegrini L (2015). A mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. Proc Natl Acad Sci U S A, 11; 111(45).

 

  • Caron A, Baraboi ED, Laplante M*, Richard D* (2015). DEP domain containing mTOR-interacting protein in the rat brain : distribution of expression and potential implications. J Comp Neurol. Jan 1;523(1):93-107. doi: 10.1002/cne.23668. (*co-corresponding)

 

  • Chabot F, Caron A, Laplante M, St-Pierre DH (2014), Interrelationships between ghrelin, insulin, and glucose homeostasis : physiological relevance. World Journal of Diabetes, 15;5(3):328-41.

 

  • Festuccia WT, Pouliot P, Bakan I, Sabatini DM, Laplante M* (2014) Myeloid-specific rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS One 9: e95432. (*co-corresponding)

 

  • Laplante M, Sabatini DM (2013) Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci 126: 1713-1719.

 

  • Birsoy K, Festuccia WT, Laplante M (2013) A comparative perspective on lipid storage in animals. J Cell Sci 126: 1541-1552.

 

  • Li Z, Miard S, Laplante M, Sonenberg N, Picard F (2012) Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway. Mol Cell Endocrinol 358: 63-68.

 

  • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.

 

  • Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, et al. (2012) DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metab 16: 202-212.

 

  • Bakan I, Laplante M* (2012) Connecting mTORC1 signaling to SREBP-1 activation. Curr Opin Lipidol 23: 226-234. (*auteur de correspondance)

 

  • Laplante M*, Sabatini DM (2011) mTOR Signaling. Cold Spring Harb Perspect Biol. Feb 1;4(2). pii: a011593. doi: 10.1101/cshperspect.a011593. (*auteur de correspondance)

 

  • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM (2010) mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468: 1100-1104.

 

  • Laplante M, Sabatini DM (2010) mTORC1 activates SREBP-1c and uncouples lipogenesis    from gluconeogenesis. Proc Natl Acad Sci U S A 107: 3281-3282.

 

  • Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, et al. (2010) Preliminary report: pharmacologic 11beta-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic    fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet. Metabolism 59: 114-117.

 

  • Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, et al. (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137: 873-886.

 

  • Laplante M, Sabatini DM (2009) mTOR signaling at a glance. J Cell Sci 122: 3589-3594.

 

  • Laplante M, Sabatini DM (2009) An emerging role of mTOR in lipid biosynthesis. Curr Biol 19: R1046-1052.

 

  • Laplante M, Festuccia WT, Soucy G, Blanchard PG, Renaud A, et al. (2009) Tissue-specific postprandial clearance is the major determinant of PPARγ-induced triglyceride lowering in the rat. Am J Physiol Regul Integr Comp Physiol 296: R57-66.

 

  • Festuccia WT*, Laplante M*, Brule S, Houde VP, Achouba A, et al. (2009) Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and  mTOR activation. J Mol Cell Cardiol 47: 85-95. (*co-premiers auteurs)

 

  • Festuccia WT, Blanchard PG, Turcotte V, Laplante M, Sariahmetoglu M, et al. (2009) The PPARγ agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake. Am J Physiol Regul Integr Comp Physiol 296: R1327-1335.

 

  • Festuccia WT, Blanchard PG, Turcotte V, Laplante M, Sariahmetoglu M, et al. (2009) Depot-specific effects of the PPARγ agonist rosiglitazone on adipose tissue glucose uptake and  metabolism. J Lipid Res 50: 1185-1194.

 

  • Berthiaume M, Laplante M, Festuccia WT, Berger JP, Thieringer R, et al. (2009) Additive action of 11beta-HSD1 inhibition and PPARγ agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats. Int J Obes (Lond) 33: 601-604.

 

  • Festuccia WT, Oztezcan S, Laplante M, Berthiaume M, Michel C, et al. (2008) Peroxisome Proliferator-Activated Receptor γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status. Endocrinology 149: 2121-2130.

 

  • Dallaire P, Bellmann K, Laplante M, Gelinas S, Centeno-Baez C, et al. (2008) Obese mice lacking iNOS are sensitized to the metabolic actions of PPARγ agonism. Diabetes, Aug;57(8):1999-2011. doi: 10.2337/db08-0540.

 

  • Laplante M, Festuccia WT, Soucy G, Gelinas Y, Lalonde J, et al. (2007) Involvement of adipose tissues in the early hypolipidemic action of PPARγ agonism in the rat. Am J Physiol Regul Integr Comp Physiol 292: R1408-1417.

 

  • Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, et al. (2007) Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. Sep;117(9):2621-37

 

  • Cui W, Paglialunga S, Kalant D, Lu H, Roy C, Laplante M, et al. (2007) Acylation Stimulating Protein/C5L2 Neutralizing Antibodies alter Triglyceride Metabolism in vitro and in vivo. Am J Physiol Endocrinol Metab, Dec;293(6):E1482-91

 

  • Berthiaume M, Laplante M, Tchernof A, Deshaies Y (2007) Metabolic action of peroxisome proliferator-activated receptor γ agonism in rats with exogenous hypercorticosteronemia. Int J Obes (Lond), Nov;31(11):1660-70.

 

  • Berthiaume M, Laplante M, Festuccia WT, Cianflone K, Turcotte LP, et al. (2007) 11-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids towards oxidative tissues. Am J Physiol Endocrinol Metab, Oct;293(4):E1045-52.

 

  • Berthiaume M, Laplante M, Festuccia W, Gelinas Y, Poulin S, et al. (2007) Depot-specific modulation of rat intraabdominal adipose tissue lipid metabolism by pharmacological inhibition of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 148: 2391-2397.

 

  • Laplante M, Festuccia WT, Soucy G, Gelinas Y, Lalonde J, et al. (2006) Mechanisms of the Depot Specificity of Peroxisome Proliferator-Activated Receptor γ Action on AdiposeTissue Metabolism. Diabetes 55: 2771-2778.

 

  • Festuccia WT*, Laplante M*, Berthiaume M, Gelinas Y, Deshaies Y (2006) PPARγagonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control. Diabetologia 49: 2427-2436. (*co-premiers auteurs)

 

  • Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, et al. (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145: 367-383.

 

  • Laplante M, Sell H, MacNaul KL, Richard D, Berger JP, et al. (2003) PPAR-γ Activation Mediates Adipose Depot-Specific Effects on Gene Expression and Lipoprotein Lipase Activity: Mechanisms for Modulation of Postprandial Lipemia and Differential Adipose Accretion. Diabetes 52: 291-299.

 

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